Pacemaker Mechanism of Porcine Sino-atrial Node Cells.
نویسندگان
چکیده
منابع مشابه
Pacemaker mechanism of porcine sino-atrial node cells.
In cardiac sino-atrial node (SAN) cells, time- and voltage-dependent changes in the gating of various ionic currents provide spontaneous, stable and repetitive firing of action potentials. To address the ionic nature of the species-dependent heart rate, action potentials and membrane currents were recorded in single cells dissociated from the porcine SAN, and compared with those from SAN cells ...
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1 The hyperpolarization-activated cation current (If) was recorded in single pacemaker cells of the porcine sino-atrial node, and the effects of genistein, an isoflavone inhibitor of tyrosine-specific protein kinases was investigated by the whole-cell patch clamp technique. 2 Genistein (20-500 microM) decreased If in a dose-dependent manner with an IC50 value of 62.3 microM and a maximum inhibi...
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The pacemaker activity of the S-A node cell was explained by reconstructing the pacemaker potential using a Hodgkin-Huxley type mathematical model which was based on the reported voltage clamp data. In this model four dynamic currents, the sodium current iNa, the slow inward current, is, the potassium current, iK, and the hyperpolarization-activated current, ih, in addition to a time-dependent ...
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In one patient reprodncibk episodes of sMal tachyear(200 msec, control; 70 msec, atropine) and sustained dia conld be elicited via programmed atrial premature atrial tachycardia no longer could be elicited. These dcpoluizations. Evllodion of the elechpphysiologic studies mpport the concept that h a t t i a l reciprocation shldks suggested that the most tikely mechanism was can be a mechanism re...
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Pacemakers were implanted in 10 of 14 patients with dizziness and syncopal episodes of long duration, due to sino-atrial block. Paroxysmal supraventricular tachycardia, notably atrial fibrillation, had occurred in 6 patients. Medical treatment was unsatisfactory in 3 of these and pacemaker therapy was given. This abolished both syncope and paroxysmal tachycardia. Sinoatrial block and supraventr...
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ژورنال
عنوان ژورنال: Journal of Smooth Muscle Research
سال: 2003
ISSN: 0916-8737,1884-8796
DOI: 10.1540/jsmr.39.195